Abstract: Quinolinone derivatives are important pharmaceutical intermediates and organic chemical materials. A synthetic method of the quinolinone derivatives was discribed. 3 - chloropropionate chloride was synthesized using 3 - chloro-propionic acid as the starting material, which was reacted with substituted aniline compounds to get the corresponding amides. The substituted amides converted to a series of quinolineone derivatives through the reaction of the Friedel-Crafts alkylation. By optimizing reaction conditions(temperature, solvent and catalyst, ect.), greatly enhanced the yield of the goal product. The advantages of this method are high yield and simple work-up. The structures of the compounds were confirmed by IR and 1HNMR.
