Chiral resolution of DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester compound
Abstract: According to raceme of nature, we have tow methods to separate the DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester. One is that adding a few of crystal of D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester to the saturated solution of the raceme make the D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester hydrochloride crystallize. The other method has the use of chiral reagents. The tartaric acid will change DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester into non-enantiomer. Ammonia was used to adjust the solution’s pH value to 7.8.That D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester precipitate. The two methods for chiral resolution are feasible.
Keywords: racemization; DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester; chiral resolution
