Elementary Research of Pharmacokinetics of fermentation Lycopene
Abstract：In this paper , Blakeslea trispora is used as the strain of fermentation. In this paper select methanol 0.8 ml/min, ethyl acetate 0.2 as mobile phase for determination of lycopene, to eliminate the two interfering substances of beta carotene and gamma carotene. In this paper , lycopene standard curve and the determination of the standard curve precision has been detected by HPLC, determining the determination method is feasible. In this paper , the content of lycopene in production also has been determined. lycopene content of product and the metabolism of lycopene in the mouae(serum :1.5h, 2.5h, 3.5h, 4.5h) has been determined. Through the detected by HPLC, lycopene in rat increases with the increasing of time form the beginning, to reach maximum at 3.5 h for 0.8 ug/ml, then began to decline.
Keywords：lyeopene; metabolism；HPLC
