Abstract: Toltrazuril is Toluene triazone for short, belonging to triazone ramification, which has good insecticidal effection, low toxicity. Toltrazuril is used for chickens, rabbits, pigeons, pigs and other livestock and poultry which infected with coccidian. Commonly it is solution, just feeding by drinking water so it is convenience to use. This article mainly discuss the synthesis of its intermediates 3-methyl-4-[(trifluoromethyl)thiophenoxy]-aniline.Comparing the literature review we conceived the synthesis routes of toltrazuril intermediate by referring lots reference. This article used 4-[(trifluoromethyl)thio]-aniline as raw materials, adopting diazo-hydroxylation hydrolysis method to synthesze the 4-[(trifluoromethyl)thio]-phenol; 4-[(trifluoromethyl)thio]ph-
enol 2-methyl-4-nitro chlorobenzene condense 3-methyl-4-[4-(trifluoromethyl)thio-phenoxy]nit-
rophenyl;In acidic solution use chemical reduction of iron synthesis of 3-methyl-4-[4-(trifluoro-
meth-yl)thiophenoxy]-aniline. From the experiments we have got high productivity of three-step reaction, 79.1%~80.8%,86.3%~88.1%,89.2%~91.0% separately, which have got expected results.
Keywords:Coccidiostatic drug; Toltrazuril; Toluene triazone