Abstract：Huanglian - rutaecarpine-right yes compatibility of typical prescription cold and heat, modern clinical applications show that berberine adjustment, the amount of rutaecarpine ratio can be used to treat a variety of functions of the spleen and stomach disorders and related diseases, such as Epigastralgia, abdominal pain, vomiting, hiccup, Diarrhea, constipation, diarrhea, anti-acid Aiqi, such as Seoul Man . How to control Huanglian - rutaecarpine drugs on the compatibility of traditional Chinese medicine is a study of the problem, and in the adjustment of the ratio of compatibility in the process of Huanglian is a question of the dissolution rate of berberine as the compatibility of the different and different. In order to study the dissolution rate of Huanglian berberine change and the reasons for the mechanism of this experiment consists of three main parts: Huanglian alkaloids in the establishment of analytical methods, like the Chinese University of rutaecarpine components and compatibility of Huanglian alkaloids and bitter-lemon Extraction Process. The results of berberine in Huanglian Diamonsil-C18 (250mm × 4.6mm, 5 μ m, Dumas) column, the mobile phase A phase of H2O-SDS-H3PO4 (1000mL: 5g: 1mL), B phase of CH3CN-H2O - SDS-H3PO4 (600mL: 400mL: 5g: 1mL); using linear gradient elution procedures: 0 min, 25% B; 15min, 50% B; 20min, 80% B; 50min, 80% B; 60min, 90% B. Flow rate of 0.8 mL / min; column temperature of 40℃; detection wavelength of 360 nm under the conditions of separation, reproducibility, precision and processing recovery than ideal. In extracts of rutaecarpine largest category of components and compatibility Huanglian berberine in the course of the dissolution rate of Huanglian Berberine has certainly reduced, but to extract and ethyl acetate after the lower maximum compatibility. Finally extracted from the plight of 0.69 g lemon.
Keywords：Rutaecarpine, Huanglian, Extraction, berberine, the dissolution rate
