摘要：探讨PH对改性钠基Mont吸附诺氟沙星的影响。模拟体内人工胃液和肠液，观察不同PH条件下改性钠基Mont对诺氟沙星吸附率的变化。改性钠基Mont吸附诺氟沙星降低了诺氟沙星的溶出，降低了它的浓度。改性钠基Mont在不同p H 溶液中对诺氟沙星均具有强大的吸附作用，两者联合用药时应避免同时服用。
关键词：改性钠基Mont；诺氟沙星；吸附；PH值
Abstract: This study was undertaken to examine the effect of the PH on the adsorption of norfloxacin by the modification of Na-montmorillonite. After simulation of artificial gastric juice and intestinal fluid in vivo, the changes of the adsorption rates of norfloxacin by Na-montmorillonite at the different PH were measured. The modification of Na-montmorillonite can adsorb Norfloxacin. It reduced the dissolution of norfloxacin. And the concentration of norfloxacin decreased. The effect of the adsorption norfloxacin by Na-montmorillonite was very strong at the different PH. Therefore, it must be avoided to administer the two drugs simultaneously.
Keyword: modification of Na-montmorillonite; norfloxacin; adsorption; PH
