Abstract: N-(4-Chlorophenyl)-2,2-dimethylpropanamide is an important intermediate for the synthesis of an HIV-1 Reverse Transcriptase Inhibitor. This study start with 4-chloroaniline, with reaction of 2,2-dimethylpropanoyl chloride. With the study of the material, the ratio of material, the reation time and the solvent, the best result is that: with the 30% aqueous sodium hydroxide, the ratio of 4-chloroaniline and 2,2-dimethyl- propanoyl chloride is 1:1.15, react at 3.5 hours, with the yield. of N-(4-Chlorophenyl)-2,2-dimethylpropanamide. 93% is got By recrystallization in ethyl acetate purification methods, HPLC was used to analyze the purity of products, mobile phase of acetonitrile: water: phosphoric acid = 40:60:0.1, detection wavelength of 245nm for C-8, a product of purity as high as 99.8%. At the same time, a preliminary study of 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone is done.
Keywords: Efavirenz; 4-chloroaniline; purification; N-(4-Chlorophenyl)-2,2- dimethylpropanamide
