Abstract：The Choline Fenofibrate Acid is a new type of lipid-lowering drugs.In this study,a new material route for preparation of Choline Fenofibrate Acid was provided. That is using Trimethylamine and Fenofibrate Acid to prepare salt in the Isopropanol, then using the salt and Ethylene Oxide to synthesize Choline Hydroxide salt and H+ as catalyst. This is a selfcatalysis reaction. In the experimental, the conditions of synthesis such as proportions, kinds of solvents, reaction time, feeding times, feeding speeds and etc.were investigated in detail and see the impact on the purity and the yield. In the best conditions,the quality of refined product is 20.93g, and the yield was reached more than 95%.The structure of the product was confirmed by IR,and the product was analysised with HPLC and the purity was morn than 99.8%.
