Abstract: Chiral epichlorohydrin is a very important synton in organic synthesis. The hydrolytic kinetic resolution(HKR) of epichlorohydrin was chosed by compared with many methods reported. The Chitosan supported (Salen)Co(Ⅲ)(OAc) catalyst was synthesized via a stepwise and the enantiomeric excess of the (S)-epichlorohydrin was determined by GC analysis. Optimization of the conditions were investigated by the mono-factor’s experiment. Under the condition that the temperature was 20℃, the water was 0.55 equivalent, and the concentration of the catalyst was 0.5mol%, the enantiomeric excess (e.e.)of the (S)-epichlorohydrin was reach 99% within 10 hours .
