Abstract: The amantadine, the derivative of adamantine, also names tricycle decane, and is widely applicated in medicine, most mainly on the anti-viral aspect. Amantadine hydrochloride is used as anti-viral medicine for a long time in clinical to treat the disease of upper respiratory tract infection caused by flu virus,and also used to treat the blood vessel of brain barrier sickness and old age dementia.
Amantadine drug has been widely used in pharmaceutical fields. In this paper amantadine was synthesized using adamantane as a starting material. The first method for synthesis of amantadine is that adamantine reacted with acetonitrile in one step, the second method is halogenation of adamantane followed by amination. The reaction conditions were optimized, by change the material’s molar rate and the starting temperature and usage of olefin.
Keywords: adamantane; amantadine; synthesis; bromine; urea
