Abstract: Fluvastatin sodium,a hypolipidemic drug,was prepared by ester hydrolysis from fluvastatin ester with 1N sodium hydroxide. In order to enrich the dosage forms of chitosan-fluvastatin combination, we choosed two kind of methods to to prepare fluvastatin-chitosan conjugate and nanoparticles. Fluvastatin was chemically coupled to chitosan to form chitosan-fluvastatin conjugate, which was confirmed by UV、IR、DSC. The size of nanoparticles was determined by laser scattering instrument. The concentration of the two kinds of chitosan- fluvastatin were determined by HPLC, then calculated the drug-loading rate. After experiment, the drug-loading rate of nanoparticles was 43.67%, and conjugate was 25.03%.
Keywords:Chitosan; Fluvastatin; conjugate; nanoparticle