Abstract:This study was to establish the technology process of the separation and purification of the fucidic acid. Fusidic acid is an efficient narrow-spectrum antibiotic. The treatment of staphylococcus aureus infection is remarkable. According to the dissolution characteristics of fusidic acid, we used the filtering, drying, extraction, column chromatography and so on to design different technics processes. HPLC was used to check the purity and yield of the products to optimize the production process of the fucidic acid. Results suggested that the yield was 44.53% and the component concentration was 98.23%. This technology process was simple, accurate, reliable and effective for the manufacturing production.
Keywords: Fucidic acid; Separation; Column chromatography; HPLC
