Abstract:Compared with many methods reported, the hydrolytic kinetic resolution (HKR) was choosed to resolute the racemic epichlorohydrin. Firstly, the (Salen)Co(III)(OAc) catalyst was synthesized and was characterized by IR. The e.e. (enantiomeric excess) of the (S)-epichlorohydrin was determined by GC analysis. Secondly, the optimization of the condition was investigated through the mono-factor’s experiment. Under the condition that the temperature was 20℃, the water was 0.55 equivalent, and the concentration of the catalyst was 0.5mol%, the e.e. of the (S)-epichlorohydrin would over 99.5% within 10 hours .
Some new kinds of Salen catalysts were synthesized, such as [(Salen)Co(II)]2(AlCl3), [(Salen)Co(II)]2(SnCl4), [(Salen)Co(II)]2(SnCl2), [(Salen)Co(II)]2(ZnCl2) and [(Salen)Co(II)]2(FeCl3). Through the comparative research on hydrolytic kinetic experiments with different Salen catalysts, [(Salen)Co(II)]2(ZnCl2) and [(Salen)Co(II)]2(FeCl3) were good catalyses. Using these two catalysts, with good condition, (S)-epichlorohydrin whose enantiomeric excess value was over 99.5% in 10 hours was got.
Keywords: Hydrolytic kinetic resolution; Salen catalyst; racemic epichlorohydrin
