Abstract: The hydrolysis of pyrimidinbenzylamine derivatives were studied by HPLC analysis in the paper. The best analysis method was adopted with C18 column (150 mm×4.6 mm, the stainless steel pillar, diamonsil (TM) diamond-type) for 8 pyrimidinbenzylamine derivatives. The methanol-water (60:40, V/V) as the mobile phase is for ZJ0777, while methanol-water (90:10, V/V) for the other compounds. Average recovery rate was 98.5~104%, The column temperature was 25℃. The calibnation curves were linear, r=0.9998. Average recovery rate was 95.47~104.93%. The kinetics process can be described by the fist-order reaction law, and the hydrolytic reaction parameters have been obtained. The experimental results show that it is helpful to the hydrolytic process via rising pH value and temperature.
Keyword: Pyrimidinyloxybenzylamine；HPLC；Hydrolysis；Kinetics
