Abstract: To prepare Curcumin-chitosan nanoparticles and study their preparation method. The drugs Curcumin- Chitosan(CS) Nanoparticles have been formed based on ionic gelation process of tripolyphosphate (TPP) and chitosan. Drug-loading rate and particle size as the indices to study a series of preparation effect factors of chitosan nanoparticles. The orthogonal experimental design applied to optimize the preparation procedure of the nanoparticles. The particle size distribution of nanoparticles was measured by laser scattering apparatus. The stable Curcumin-chitosan nanoparticles was prepared. Average size of 220 nm, Encapsulation efficiency 10%,Average Drug-loading rate 30%. Chitosan concentration, pH value of the system, Sodium Tripolyphosphate(TPP) concentration, Lyoprotectents are all the main effect factors of nanoparticles preparation.
Keywords: Curcumin;Chitosan;Nanoparticles;Sodium Tripolyphosphate