蛋白质多肽类药物口服给药的研究进展

蛋白质多肽类药物口服给药的研究进展

摘要：本文综述了近年来蛋白质多肽类药物口服给药的研究进展。蛋白质多肽类药物口服给药的研究对现代疾病的预防和治疗至关重要。由于蛋白质多肽类药物在消化道内易被破坏，市售蛋白质多肽类药物主要以注射为主。但是频繁的注射会给病患带来极大的痛苦，因此口服成为了研究的焦点。大量研究证明，运用结构修饰、应用吸收促进剂、酶抑制剂、制备新型载药等方法，可以提高蛋白质多肽类药物在肠道内的稳定性，并提高其口服生物利用度，使蛋白质多肽类药物口服给药展现出更美好的前景。

关键词：蛋白质多肽类药物；口服给药；研究进展

The research of protein peptide drugs for oral administration

Abstract: This paper reviews recent oral administration of peptide drugs research. Proteinprptide drugs for oral administration study of modern disease prevention and treatment is essential. As the protein peptide drugs susceptible to damage in the digestive tract, commercially available protein-based peptide drugs mainly injected. However, patients with frequent injections will bring great pain, so oral as a research focus. Numberous studies have demonstrated the use of structural modification, the application of absorption enhancers, enzyme inhibitors, such as preparation of new drug delivery methods, the protein peptide drugs increase the stability in the intestine and increase its oral bioavailability, protein peptide drugs oral administration show a more promising future.

Keywords: Protein peptide drugs; Oral administration; Researrch

目录

引言 2

1 蛋白质多肽类药物口服生物利用度的影响因素 2

1.1 胃肠道粘膜的低渗透性 2

1.2 胃酸和胃肠道酶的降解作用 2

1.3 首过效应和吸收部位 2

2 蛋白多肽类药物口服给药研究的一些新进展 3

2.1 化学修饰 3

2.1.1 前药策略 3

2.1.2 结构修饰 3

2.2 制剂技术 4

2.2.1 吸收促进剂 4

2.2.2 酶抑制剂和P—gp抑制剂 4

2.2.3 生物黏黻系统 5

2.2.4 定位释药系统 6

3 结语 6

参考文献： 7