Study on the Preparation and Application of N-benzyl Chitosan Derivatives
Abstract: This paper introduce the synthesis of N-benzyl derivative through benzaldehyde and chitosan Schiff reaction and was characterized by IR. Determination of furfural derivatives by absorbance, we found N-benzyl derivatives of bile acid binding capacity of chitosan was higher than chitosan. Though using Feton reagent of hydroxyl radical and the color determination of salicylic acid, we tested N-benzyl chitosan derivatives of the hydroxyl radical OH-scavenging ability, the results show that it is have scavenging ability. Use of pyrogallol autoxidation method, we tested N-benzyl chitosan derivatives on O2-superoxide free radical scavenging, the results show also has scavenging, and we discussed the N-benzyl chitosan derivatives solubility and concentration on the scavenging effect. The preparation of N-benzyl modified improved solubility , thus enhancing the free radical scavenging. However, a decrease of NH2, the free radical scavenging ability of thus N-benzyl chitosan derivatives was lower.
Key words: Chitosan; N-benzyl chitosan derivatives; Bile acid binding capacity; Free radical scavenging capacity
