Abstract: Chiral alcohols is the most important organic compund in the most medicament pesticide and functional material .The one major of method to get the chiral alcohols parallelism excessive percent(ee value) is by the chiral amino alcohols ligand catalytic reduction of prochiral ketone .This thesis is on the basis of relative reference and summarize the development of the dissymmetry catalyse reaction.
In order to find the performance outstanding reminders body. On the basis of more catalytic center ligand cooperate with the asymmetric catalytic reduction reaction. we can get chiralalcohols higher value ee. We use the (1S,2R)-(+) and (1R,2S)-(-)-2-amino-1,2-dipheny -lethanol two chiral source and 2,4,6-trimethyl-1,3,5-tribenzylbromide reaction separately. After optimizing the reaction conditions in ethanol solution. under the 70℃. Use KI as a catalyst for hydrogen K2CO3 agent first synthesized by the catalytic center with three ligand. 2,4,6- trimethyl-1,3,5-tri-[N-(1’R,2’S)-(1’,2’-diphenyl-2’-hydroxy)ethyl]benzylamineand2,4,6-trimethyl-1,3,5-tri-and2,4,6-trimethyl-1,3,5-tri-[N-(1’S,2’R)-(1’,2’-diphenyl-2’-hydroxy)ethyl] by silica -gel column chromatography in the colorless crystals. and the yield 38 % and 40 %. Product by IR. 1H NMR. MS is confirmed. Then we obtain the good validate for the series of antimer. Spectral properties.the melting point and specific rotation other physical constants.
