Abstract: In this paper, we have used the orthogonal testing method to conventional method as well as the microwave radiation synthesis of amyl salicylate. then has worked out the optimized condition with intuitive analysis. In the conventional method, we have research different proportion of pentanol and salicylic acid, different mix blend velocity, different quantity of Sulfuric acid volume and different reaction time as four factors. Using L16 (44) orthogonal test and intuitive analysis ,the result enunciate that the most suitable and proper reaction conditions is that: the proportion of pentanol and salicylic acid is 5:1,mix blend the velocity is 300r/min, the Sulfuric acid volume is 1.6 mL, and reaction time is 4 hours, and the ester produces a rate of 76.40%. Then we complete synthesis of amyl salicylate at microwave radiation. It investigated the yield of ester by using different proportion of pentanol and salicylic acid, different quantity of sulfuric acid volume, different reaction temperature ,different reaction time . Using L16 (44) orthogonal test and intuitive analysis, the result enunciate that the most suitable and proper reaction conditions is that: the proportion of pentanol and salicylic acid is 3:1, the Sulfuric acid volume is 1.1 mL, reaction temperature 120℃,reaction time is 40 min, then the ester produces a rate of 84.79%. By comparison, the result shows that when microwave radiation technology was used in esterification, we can get short reaction times and high yields.
