Abstract: This paper focuses on the synthesis of cinchona alkaloid catalysts which contains rigid polybenzene moieties and their application in asymmetric catalytic reactions. Thus this experiment introduces a rigid polybenzene moiety (TPPh) to the bridge nitrogen atom of cinchona alkaloids to prepare a series of novel catalysts, which is further used as catalysts for the asymmetric alkylation of tert-butyl glycinate-benzophenone Schiff base. In the Model reaction, it investigates and compares the catalytic activity and enantioselectivity of the novel catalysts with other common catalysts derived from cinchona alkaloid with benzyl chloride or other small groups.
This study of the Model response to the diphenyl imine and diphenyl imine tert-butyl glycine, and the catalyst of raw materials for the intermediates - 4 phenyl acid, 4 phenyl benzyl alcohol, 4 phenyl benzyl chloride and finally gets the target catalysts. The experimental results of the novel catalyst in the Model reaction is not fully collected due to deficient time. However, It is now in progress in labs.
KeyWords：cinchona alkaloid derivatives;TPPh;asymmetric reaction;α-Amino Acids
