Based on e-commerce supply chain management has become a new competition, becoming the new issue of the enterprise concerned. This article in reference to domestic and foreign e-commerce, supply chain management research, primarily from the perspective of qualitative on e-business and supply chain management, features and advantages. Secondly explains the issues in the supply chain and make the appropriate analysis, such as technical issues, information sharing and partnership. On this basis in enterprise e-commerce supply chain management problems and solutions, tried to build appropriate e-business era new mode of supply chain management.