Abstract: This study was undertaken to examine the analgesic effect of ketoprofen. Mice delayed-type hypersensitivity test, using reagents sensitized after administration; mouse writhing test, after administration by intraperitoneal injection of 0.6% acetic acid, records writhing and 15min incubation period with the number of writhing in mice ; immune tests， mice the first six days, in addition to the normal group, the remaining group by intraperitoneal injection of cyclophosphamide 60mg/kg model, modeling the first two days, by intraperitoneal injection of 20% sheep red blood cell 0.2ml / only immune animals , 5 days after immunization to experiment. As the results Ketoprofen can significantly increase the pain threshold in mice and prolong the incubation period writhing. The analgesic effect of ketoprofen is obvious.
Keywords：Ketoprofen; Delayed type Hypersensitivity; Turning the body to determine the threshould of pain; Immunization;analgesia action
