Abstract: Chiral alcohols is a natural product and the importance intermediate of chiral drugs synthesis as well as chiral synthesis of functional materials. One of the important ways to acquire chiral secondary alcohols high enantiomeric excess percentage(e.e.value) is by chiral amino alcohols ligand catalytic reduction of prochiral ketone access. Chiral alcohol has become one of the most active research areas in recent years. In this paper, the inspection on the basis of relevant information summarizes the asymmetric catalytic reduction reaction of new progress.
In order to find high performance catalyst remains, based on more catalysis center ligand in asymmetric catalytic reduction of synergies, can achieve available chiral secondary alcohols higher e.e.value. We were respectively using (1S,2R)-(+) and (1R,2S)-(-)-2-amino-1,2-diphenyl ethanol as chiral sources with 1,3-benzyl bromide reponse by optimizing the reaction conditions in acetonitrile solution, in 65℃, KI as a catalyst and K2CO3 as a hydrogen absorption reagent first synthesized the catalysis center with two ligand, N-(1＇R,2＇S)-(1＇,2-diphenyl-2＇-hydroxyl) ethyl-1,3-benzyl amine and N-(1＇S,2＇R)-(1＇,2-diphenyl-2＇-hydroxyl) ethyl-1,3-benzyl amine, by silica gel column chromatography get the colorless crystal. It has good yield.
