Abstract: This paper discussed the synthesis of ethyl bromodifluoroacetate and further explored the process of ethyl bromodifluoroacetate. Considering the factors such as profit, wastes’ recycling and industrial production, 1,1-difluoro -1,2,2- trichloroethane was chosen as the raw material. The process followed as below: first, dehydrochlorination, second, bromination, and third esterification. The purity of the product was analyzed and detected by GC1690. The optimal reaction conditions as following: ethanol as solvent, 1.3 equivalent of sodium hydroxide for reaction, condensation reaction temperature was 50℃, the temperature of esterification was 35℃, the best yield of ethyl bromodifluoroacetate was 67%.