Abstract: Meloxicam is a non-steroidal anti-inflammatory drugs. It has a strong anti-inflammatory analgesic effect. Clinical studies show that meloxicam is effective in treating rheumatoid arthritis and osteoarthritis. Compared with traditional anti-inflammatory drugs, meloxicam is safer, long-lasting, less side effects. In this thesis, the content of meloxicam was assayed by ultraviolet spectrophotometry method in preparations. High performance liquid chromatography was used to study the stability of meloxicam and to detect the related substances and degradation products of meloxicam. The results show that meloxicam maximum absorption at wavelength of 372nm. In the range of 0.580 ~ 0.869μg/ml, a good linear relationship isaccepted with, the availability of the regression equation: Y = 0.4785X +0.0138, R = 0.9996; U.S. Related substances and degradation products of meloxicam was determined by RP-HPLC, with the mobile phase 0.05mol / L ammonium dihydrogen phosphate (pH4.5) - methanol (47:53), the detection wavelength: 370nm. The results suggest that meloxicam is instable on acid, oxidants, light couditions and it is stable on alkali and heat couditions.
Keywords：UV - Vis Spectrophotometry；HPLC；Meloxicam
