Abstract: In this paper, the existing literature on the basis of a brief description of the antiepileptic drug therapy, with a focus on antiepileptic drug (S) -2 - ethyl -2 - O -1 - pyrrolidine acetamide Technology. Screening for 2 - bromo-butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam. Methods used in esterification HCL / methanol and dichloro-sulfoxide and sulfuric acid to carry out experimental research aminate methanol saturated amines were used, plus salt, add water, three options to conduct experiments. Resolution of the use of non-resolution of enantiomers methods used in organic solvents tartaric acid for the separation agent, to be S-type. At the same time, this paper also split the R-isomer of racemic to change and re-recovery. Another direct use of this experiment (S )-(+)- 2 - tartaric acid amide ammonium salt hybroxybutyric cyclization experiments skip the first preparation of (S )-(+)- 2 - ammonia hybroxybutyric amide hydrochloride, and then related Preparation of Levetiracetam ring step. The synthetic route for the 25% overall yield. The process line is simple, low cost, high yield, large-scale production can be industrialized.
Keywords: Synthesis; Levetiracetam ; Antiepileptic drug
