Abstract: Benzylisothiocyanate is unstable as aromatic sulfur-containing active compounds. It could be embedded into β-cyclodextrin in order to improve its stability by the β-cyclodextrin inclusion technology. In this experiment, the quantitative analysis method of β-cyclodextrin - benzyl isothiocyanate complex was studied. In order to improve the inclusion ratio, response surface central composite design pattern was used. The inclusion parameters was optimized and variance analysis was conducted. The results showed that the best embedding conditions to prepare the β-cyclodextrin - benzyl isothiocyanate inclusion complexes:β-cyclodextrin: BITC (g:mg) is 0.174, inclusion temperature is 55.320C, in this optimum conditions, the inclusion ratio is 96.09%. The developed inclusion process has the advantages of low cost, simplicity, thereby providing a promising approach for the prolongation of the stability of benzyl isothiocyanate.
Keywords：benzyl isothiocyanate;β-cyclodextrin;inclusion technology;response surface analysis
