Abstract: Isothiocyanate(ITC) is the degradation product of glucosinolate (GS) which is secondary metabolite including sulfur with anti cancer activity. Benzylisothiocyanate(BITC) and phenzylisothiocyanate(PEITC) are two important biological activity compounds with remarkable anticancer activity. But they are unstable in normal temperature and easy to volatilize and destroyed by light, heat and oxygen, and so on. β-Cyclodextrin (β-CD) was selected as wall-material and the embedding technology of β-CD –BITC and β-CD-PEITC was studied. TO investigate the effects of different quality ratio of ITC and β-CD, inclusion temperature and the agitation speed on inclusion ration and inclusion degree, an orthogonal test comprising nine test runs based on these factors at three different concentrations were carried out. The quantificative analysis method was established. The results showed that the optimum conditions were A3B3C1 and A1B3C3 with embedding ratio as objection, while A1B3C3 and A1B2C2 with embedding degree as parameter.
关键词:β-环糊精;苯甲基异硫代氰酸盐;苯乙基异硫代氰酸盐;包埋