Abstract:With the developing of chemical industry and in-depth studying of chitosan, people found that chitosan has many excellent characteristics, which attracted more attention. In this topic prepared the chitosan L-lactic acid with high degree and low molecular of deacetylation, Aim to increase the concentration of ammonium by improving the degree of deacetylation Chitosan, and L-lactic acidifying at the same time; increasing the intensity of ammonium to further increase its water-soluble; small molecular Chitosan has good water-solubility, easy accessing to the bacterial cell membrane, thus enhancing its bacteriostatic and bactericidal effects. We used phase transfer catalyst to improve the deacetylation of Chitosan, and the hydrogen peroxide degradation to reduce the molecular of Chitosan. High degree of deacetylation and low molecular Chitosan L-lactate which has good solubility in water has good antibacterial effects. It has broad prospection in the field of ophthalmic medication.
Key words: low molecular weight chitosan ; high deacetylation degree ; Phase transfer catalyst ; hydrogen peroxide depolymerization ;