Abstract: L-Ergothioneine is a rare natural amino acid, important in vivo biological activity, but cannot synthesize from vivo synthesis, it can only be obtained from the diet. Overseas research shows that it can play an effect and safety role in vivo antioxidant, non-toxic, naturally and ideally. Methyl L-histidinol dihydrochloride as the raw material, benzoyl chloride, concentrated hydrochloric acid for accessories, in tetrahydrofuran, methanol and other solvents, synthesize ergothioneine. this article’s objective is to synthetize ergothioneine, using intermittent - multi-step reaction, and gradually obtained the target product ergothioneine. in order to improve the rate of production ,we separate one step to two steps .After every step ,we determinate the productions with the nuclear magnetic resonance(NMR) spectroscopy and IR spectra with the target production which is prepared in the previous time ,eliminating the side effects which may take place in the reaction. Under the same conditions, different reaction temperature and concentration of contrast test, we adjust the reaction conditions appropriate to achieve the optimization of the synthetic product.
Keywords：L-Ergothioneine; Antioxidant; Chemical reaction temperature; The nuclear magnetic resonance(NMR) spectroscopy and IR spectra.
